Seagen

Scientist, Small Molecule Process Development

Technical Operations & Process Sciences - Bothell, United States

Description

Seagen is a global, multi-product biotechnology company dedicated to developing and commercializing transformative cancer medicines. As the industry leader in antibody-drug conjugate (ADC) technology, we pioneered a new generation in the science of harnessing antibodies to deliver cell-killing agents directly to cancer cells. Seagen’s dedication to improving the lives of cancer patients goes beyond science, and we believe that every employee has a role in contributing to this mission. By working together with a shared dedication and diverse perspectives, we are able to reach our full potential and make a real difference in the world. Seagen is a fast-growing company and has an abundance of opportunities available for you to grow your career. Put your passion to work at Seagen and join us!

Position Summary:

Seagen’s Small Molecule Process Development is responsible for the development of drug-linkers and small molecule APIs from Research to market authorization. This work is based on interdisciplinary collaboration among synthetic chemistry, engineering, analytical chemistry, and biotechnology. Our scientists develop innovative solutions to accelerate research programs to the clinic, and tech transfer processes to external partners for pre-clinical and clinical materials supply. The ideal candidate must have strong technical knowledge with practical experience in process engineering combined with the spirit of innovation and an efficient approach to problem solving.

Principal Responsibilities:

• Apply engineering fundamentals towards developing drug-linker and small molecule processes at lab, pilot, and manufacturing scales
• Understand unit operation design, process modeling and optimization, process equipment selection, and scale-up methodologies
• Collaborate with process chemists and analytical chemists on synthetic strategy and route development
• Design, implement, and interpret data rich experiments independently
• Utilize various process modeling approaches to ensure robust tech transfer to pilot and commercial scale facilities
• Develop and implement new technologies for process improvement at external manufacturing partners

Required Qualifications:

• Laboratory experimental skills
• Experience using automated reactor and sampling systems
• Experience building reaction or unit operation models with software such as DynoChem®, Reaction LabTM, ASPEN, and MatLab
• Knowledge and experience applying Design of Experiments
• Strong organization, time management, and problem-solving skills
• A team player with good communication skills, desire to achieve team and individual goals
• Strong technical writing and presentation skills
• A BS, MS, or Ph.D. degree in chemical engineering or a related field is required
• BS with 10+ years, MS with 8+ years, or Ph.D. with 1+ years of process development experience in the biotechnology or pharmaceutical industry

Preferred Qualifications:

• Experience using Process Analytical Technologies (PAT) such as Raman, FTIR, NIR, on-line HPLC, and FBRM
• Experience with separation processes such as Tangential Flow Filtration (TFF), membrane separation, chromatography purification, or Supercritical Fluid Precipitation/Extraction
• Knowledge of / experience with flow chemistry systems
• Experience with technical transfer of processes into external manufacturing partners

As the leading employer in our industry in the Pacific Northwest, Seagen is proud to offer a competitive total compensation package as well as a comprehensive benefits program designed to support the whole lives of our employees and their families. Benefits include medical, vision and dental coverage, group and supplemental life insurance, 401(k) with company match, tuition reimbursement, relocation assistance and much more. To learn more about Seagen, please visit www.seagen.com.

The hiring pay range for this position is $100,000 to $130,000 per year based on skills, education and experience relevant to the role. Other components of total compensation include a competitive equity grant at the time of hire (with additional annual grants, and grants upon promotion when applicable), and an annual bonus.

Seagen is an equal opportunity employer. All qualified applications will receive consideration for employment without regard to race, age, gender identity, sexual orientation, color, religion, sex, marital status, national origin, protected veteran status, disability status, or any other status protected by federal, state, or local law.

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Seagen

Seagen is an Equal Opportunity Employer

Submitted: 09/15/2023